PHASAGE

PhasAGE – Excellence Hub on Phase Transitions in Aging and Age-Related Disorders

Training SCHOol 1

Computational Methods to Study Protein Phase Separation

24-28 MAY 2021 | 2-6 PM CEST

ONLINE COURSE

DESCRIPTION

The Training School “Computational Methods to Study Protein Phase Separation” is the first edition of a series of PhasAGE training activities.

Participants will receive training in a multidisciplinary environment, and acquire knowledge on integrative methodologies required to study phase transitions in vitro and in cells.

The goal of this course is to provide participants with the basic knowledge to understand the phenomenon of Phase Separation, its role in biological processes and diseases. In addition, the course will provide an overview of the available computational resources to navigate this knowledge. Participants will have hands-on training in tools and resources available for life sciences, to collect information from the literature on biomolecular phase transitions, identify features triggering phase transitions, mutations associated with diseases, known or predicted PTMs and molecular interaction sites.

ORGANIZING INSTITUTION

University of Padova (Italy)

Organizing committee

Prof. Silvio Tosatto (University of Padova)
Dr. Lisanna Paladin (University of Padova)
Dr. Alex Monzon (University of Padova)
Dr. Federica Quaglia (University of Padova)
Diana Battistella (University of Padova)

Keywords

phase separation, protein structure, protein aggregation, disordered proteins, repeated proteins, protein interactions, protein function, biological processes, diseases, aging

FINAL PROGRAM

Monday | 24 May

14:00-14:45

PhasAGE: Excellence Hub on phase transitions in aging and age-related disorders

Sandra Macedo Ribeiro | IBMC/i3S, University of Porto, Portugal 

14:45-16:30

Phase separation and emergent functions of Intrinsically Disordered Proteins

Peter Tompa | VIB-VUB, Belgium

16:30-16:45

Break

16:45-18:00

Group Activity

Tuesday | 25 May

14:00-14:30

Overview of bioinformatics tools for the life sciences

Silvio Tosatto | University of Padova, Italy

14:30-15:30

Classification and evolution of non-globular proteins

Silvio Tosatto | University of Padova, Italy

15:30-15:45

Break

 

15:45-17:15

Computational prediction and databases of protein phase separation: overview & practical session

Alexander Monzon & Federica Quaglia | University of Padova, Italy

17:15-18:00

Group activity

Wednesday | 26 May

14:00-14:45

Biophysical principles and molecular features of protein phase separation

Antonio Trovato | University of Padova, Italy

14:45-15:30

Computational prediction and databases of protein phase separation: overview

Balint Meszaros | European Molecular Biology Laboratory, Germany

15:30-15:45

Break

15:45-16:45

Linear motifs identification and prediction: practical session

Balint Meszaros | European Molecular Biology Laboratory, Germany

16:45-17:30

Protein aggregation prediction: overview & practical session

Salvador Ventura | Autonomous University of Barcelona, Spain

17:30-18:00

Group activity

Thursday | 27 May

14:00-15:00

Phase separation in virus-host interactions

Sonia Longhi | Center for the National Scientific Research, France

15:00-15:45

Computational prediction and databases of protein phase separation: overview

Alexander Monzon & Federica Quaglia | University of Padova, Italy

15:45-16:00

Break

16:00-17:30

Computational prediction and databases of protein phase separation: practical session

Alexander Monzon & Federica Quaglia | University of Padova, Italy

17:30-18:00

 

Group activity – social event

Friday | 28 May

14:00-15:00

Phase separation in diseases

Zsuzsanna Dosztanyi | Eötvös Loránd University, Hungary

15:00-15:45

Structure and protein interactions of repeated and low complexity regions

Vasilis Promponas | University of Cyprus, Cyprus

15:45-16:00

 

Break

16:00-16:30

Structure and protein interactions of repeated and low complexity regions: practical session

Vasilis Promponas | University of Padova, Italy

16:30-18:00

 

Group activity

18:00-18:15

Closing remarks

TARGET AUDIENCE AND REQUIREMENTS

This course is intended for Master students, PhD students and young researchers that have a basic understanding of protein structure and function and the cell system. Participants are not required to have computational or programming skills, but to be familiar with the navigation of online biological resources.

Some sessions will be open to the public for attendance. Practical sessions are limited to 25 attendees to maximize active learning. Participants will be selected based on their CV and motivation statement and will receive a certificate of completion

Requirements – A stable internet connection, experience in an operating system and a Internet browser.

INSTRUCTORS

Prof. Sandra Macedo Ribeiro (University of Porto, Portugal)

Prof. Peter Tompa (VIB-VUB, Belgium)

Prof. Salvador Ventura (Autonomous University of Barcelona, Spain)

Prof. Zsuzsanna Dosztanyi (Eötvös Loránd University, Hungary)

Prof. Vasilis Promponas (University of Cyprus, Cyprus)

Prof. Silvio Tosatto (University of Padova, Italy)

Prof. Antonio Trovato (University of Padova, Italy)

Dr. Sonia Longhi (Center for the National Scientific Research, France)

Dr. Balint Meszaros (European Molecular Biology Laboratory, Germany)

Dr. Alexander Monzon (University of Padova, Italy)

Dr. Federica Quaglia (University of Padova, Italy)

 

Course duration – 13 hours 15 minutes

FEES

Course and registration are free of charge. PhasAGE will not cover any expenses incurred by the participants.

In collaboration with

REFRACT has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 823886.

IDPfun has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 778247

The ELIXIR-Europe Intrinsically Disordered Proteins Community

Patronage

SIB – Società Italiana di Biochimica e Biologia Molecolare

PhasAGE is a Twinning project fully committed to gender balance by developing and supporting a diverse and inclusive community.