PhasAGE – Excellence Hub on Phase Transitions in Aging and Age-Related Disorders
EXPERT SEMINAR SERIES
The PhasAGE Expert Seminars consist of a series of talks with speakers from PhasAGE partner’s institutions to promote a successful transfer of knowledge about PhasAGE topics – biomolecular phase separation, aging and age-related diseases – between the partners of the consortium.
The seminars are integrated into visiting actions between the institutions to create an interdisciplinary environment for collaborative research on biomolecular phase transitions.
Due to the Covid-19 pandemic situation, the seminars scheduled for the year 2021 will be exclusively online.
Online seminars will include a 30 min talk followed by a Q&A session. Registration is free but mandatory.
PhasAGE members will have access to a closed Q&A session with the speaker after each seminar.
14 June 2021 - 3 PM CEST | ONLINE EVENT
Inhibition of age-associated genomic instability: emerging strategy to delay cellular senescence and aging
Since 2015 E. Logarinho (EL) leads the Aging & Aneuploidy group, dedicated to high-profile research on the mechanisms of cell cycle deregulation and genomic instability contributing to aging and age-related diseases. The group applies interdisciplinary approaches to address how regulated instruction of proliferative fitness and genomic stability decelerates senescence in mouse models of Down syndrome, progeria and aging. Within i3S Cancer Program, EL is tackling the question on how aging is the major risk factor for tumorigenesis, with focus on chromosomal instability and senescence. EL is currently vice-coordinator of the Cancer Program and member of the Restrictive Scientific Council.
One of the major goals of aging research is to develop strategies to delay and even reverse aging. Emerging findings indicate that genomic variations are a relevant and under-recognized mechanism underlying human aging and age-related diseases. Our group has been focused on genetic and pharmacological interventions protecting against genomic instability and addressing their impact in senescence accrual. Our recent findings will be presented.
Chairs: Javier Garcia-Pardo (UAB) and Susanna Navarro (UAB)
26 April 2021 - 3 PM CEST | ONLINE EVENT
Phase Separation: an emergent function of disordered proteins
Director of VIB’s Structural Biology Research Center in Belgium. Peter is also a professor of biochemistry at the VUB (Free University Brussels), and at the Institute of Enzymology, Research Centre for Natural Sciences, Hungarian Academy of Sciences (Budapest, Hungary).
Peter Tompa is an expert in structurally disordered proteins and phase separation research in cell physiology and disease.
Intrinsically disordered proteins (IDPs) lack a well-defined structure, yet they fulfil important functions in the cell. It was recently recognized that they can undergo physiological condensation (liquid-liquid phase separation, LLPS) leading to the formation of cellular membraneless organelles (MLOs), such as the nucleolus and stress granules. Due to its prevalence and importance in cell physiology and pathology, the mechanism of LLPS is recently under intense scrutiny. This seminar will cover key aspects of LLPS and the formation of MLOs, and highlight basic conceptual, computational and experimental challenges of this new field.
Chairs: Isabel Cardoso (IBMC/i3S) and Ana Rita Costa (IBMC/i3S)