PHASAGE

PhasAGE – Excellence Hub on Phase Transitions in Aging and Age-Related Disorders

TOOLBOX

The Toolbox gathers computational online resources and experimental protocols to study protein phase separation. It serves the scientific community and industry stakeholders by sharing websites, online platforms – databases and prediction algorithms tools – and guidelines for the study of protein phase separation. Part of these computational tools and databases were developed by members of the PhasAGE consortium in a collaborative effort for advancing computational biology and bioinformatics research. 

DATABASES

Proteins driving liquid-liquid phase separation in living cells

Protein intrinsic disorder annotation

Protein disorder and mobility annotations

Annotated tandem repeat protein structures

Fuzzy protein complexes

PREDICTORS

Protein liquid-liquid phase separation

Repetitive structures and units in tandem repeat proteins

Amyloid STructural Aggregation

Protein SOlubility based on Disorder and Aggregation 

“hot spots” of aggregation in polypeptides

Aggregation propensity in protein structures and rational design of protein solubility

Protein disorder over pH for IDPs/IDRs

Aggregation propensity of IDPs based on the environmental pH