PHASAGE

PhasAGE – Excellence Hub on Phase Transitions in Aging and Age-Related Disorders

TOOLBOX

Repository of computational resources and experimental protocols – websites, databases and prediction algorithms tools, and standard guidelines – for the study of protein phase separation. Part of these computational tools and databases were developed by members of the PhasAGE consortium in a collaborative effort for advancing computational biology and bioinformatics research. 

DATABASES

Proteins driving liquid-liquid phase separation in living cells

Protein intrinsic disorder annotation

Protein disorder and mobility annotations

Annotated tandem repeat protein structures

Fuzzy protein complexes

Structure-based predictions of protein aggregation (human proteome)

Cryptic Amyloidogenic Regions in Intrinsically Disordered Proteins

PED

Structural ensembles, including intrinsically disordered proteins

PREDICTORS

Protein liquid-liquid phase separation

Repetitive structures and units in tandem repeat proteins

Amyloid STructural Aggregation

Protein SOlubility based on Disorder and Aggregation 

“Hot spots” of aggregation in polypeptides

Aggregation propensity in protein structures and rational design of protein solubility

Protein disorder over pH for IDPs/IDRs

pH-dependent Aggregation of Intrinsically Disordered Proteins

Impact of mutations on the aggregation propensity of prion-like proteins

Exposed Amyloidogenic Regions (EARs) located within IDRs