PHASAGE

PhasAGE – Excellence Hub on Phase Transitions in Aging and Age-Related Disorders

phasage international conference

Phase transitions in aging and age-related diseases

12-14 OCTOBER 2021

Virtual Conference

DESCRIPTION

The PhasAGE consortium invites you to participate in the I PhasAGE International Conference “Phase Transitions in Aging and Age-related Diseases” that will be held online from 12 to 14  October 2021. 

The conference will bring together members of the PhasAGE consortium and external speakers showcasing high impact achievements in the field of liquid-liquid phase separation in aging and late-onset diseases.

The scientific program includes a scientific symposium organized by the group of early stage researchers. Young researchers and junior postdocs will have access to a workshop in alternative careers in science.  

CONFERENCE PROGRAM

(All indicated times are Lisbon/London time)

DAY 1 | 12 October

Afternoon

14:00-14:15

Opening session

14:15-15:15

KEYNOTE LECTURE I

Chair: Peter Tompa

Biomolecular condensates at the nexus of stress, protein aggregation disease and ageing | Simon Alberti, Technische Universität Dresden, Center for Molecular and Cellular Bioengineering – CMCB

15:15-15:30

Coffee Break

15:30-17:00

Session I – Phase separation in cellular function and disease

Chairs: Eurico Morais Sá & Reto Gassmann

15:30-16:00

Role of phase separation in the assembly of adhesion junctions | Alf Honigmann, Max Planck Institute of Molecular Cell Biology and Genetics, Germany

16:00-16:30

A first extracellular prion-like protein | Salvador Ventura, Autonomous University of Barcelona, Spain

16:30-17:00

Phase separation in telomere maintenance of telomerase-free cancer cells | Huaiying Zhang, Carnegie Mellon University, USA

17:00-17:15

Coffee break

17:15-17:45

SELECTED SHORT TALKS | SESSION I

Chair: Isabel Castro

17:15-17:30

Hecw controls oogenesis and neuronal homeostasis by promoting the liquid state of ribonucleoprotein particles | Simona Polo, Fondazione Istituto FIRC di Oncologia Molecolare, Italy

17:30-17:45

RNA-binding and prion domains: the Yin and Yang of phase separation | Natalia Sanchez de Groot, Autonomous University of Barcelona, Spain

DAY 2 | 13 October

Morning

10:00-11:00

Workshop | Alternative Careers in Science

Chairs: Sandra Macedo-Ribeiro & Paula Lopez-Perez

Afternoon

13:00-15:10

Session II – PHASE SEPARATION IN CELL QUALITY CONTROL AND NEURODEGENERATIVE DISEASES

Chairs: Ludo Van Den Bosch & Alexandra Moreira

13:00-13:30

The role of liquid-liquid phase separation in amyotrophic lateral sclerosis | Donya Pakravan, VIB-VUB Center for Structural Biology, Belgium

13:30-14:00

Condensate targeting as a strategy to prevent irreversible protein aggregation: implications for ALS and FTD | Serena Carra, University of Modena and Reggio Emilia Modena, Italy

14:00-14:30

Mechanistic insights into the promotion or inhibition of phase separation by polyubiquitin chains of different linkages | Carlos Castañeda, Syracuse University, USA

14:30-14:40

Coffee break

14:40-15:10

The Yin and Yang of RNA in neurodegeneration | Annalisa Pastore, Kings College London, UK

15:10-15:40

SELECTED SHORT TALKS | SESSION II

Chair: Vítor Teixeira

15:10-15:25

The S100B chaperone precludes formation of Tau puncta and liquid-liquid phase separation | Cláudio Gomes, Biosystems & Integrative Sciences Institute, Faculdade de Ciências, Universidade de Lisboa, Portugal

15:25-15:40

α-Helical peptidic scaffolds to target α-synuclein toxic species with nanomolar affinity | Jaime Santos, Autonomous University of Barcelona, Spain

15:40-15:50

Coffee break

15:50-17:20

Session III – ESR symposium

Chair: Carlos Conde & Tiago Gião

15:50-16:20

Non-coding RNAs and phase separation rule the world! | Gian Tartaglia, Istituto Italiano di Tecnologia, Italy

16:20-16:50

Intrinsic disorder, phase separation and fibrillation by the Henipavirus V and W proteins | Sonia Longhi, Center for the National Scientific Research, France

16:50-17:20

Phase transitions in telomere structure and function | Amy Strom, Princeton University, USA

DAY 3 | 14 October

Morning

11:00-12:00

SELECTED POSTER SPEED-TALKS SESSION  

Chairs: Rita Vilaça & Mónica Lopes-Marques

Afternoon

13:00-14:00

KEYNOTE LECTURE II

Chair: Sandra Macedo-Ribeiro

Stopping amyloid formation by targeting the early culprits of aggregation | Sheena Radford, The Astbury Centre for Structural Molecular Biology, University of Leeds, UK

14:00-14:10

Coffee break

14:10-15:40

Session IV –  Molecular and structural aspects of phase separation

Chairs: Pedro Martins & Alexander Monzon

14:10-14:40

The generic nature of the condensed state of proteins | Monika Fuxreiter, University of Padova, Italy

14:40-15:10

Prion-like nucleation in biomolecular condensation | Peter Tompa, VIB-VUB Center for Structural Biology, Belgium

15:10-15:40

Tunable properties and dynamics of biomolecular condensates | Shana Elbaum-Garfinkle, Advanced Science Research Center – The Graduate Center of the City University of New York, USA

15:40-15:55

Coffee break

15:55-16:25

SELECTED SHORT TALKS | SESSION III

Chair: Susanna Navarro

15:55-16:10

Surface tension effects on the nucleation-and-growth of phase separated proteins | Pedro Martins, Instituto de Investigação e Inovação em Saúde, Portugal

16:10-16:25

A generic approach to study the kinetics of liquid–liquid phase separation under near-native conditions | Luis Fernando Durán Armenta, VIB-VUB Center for Structural Biology, Belgium

16:25-16:40

Closing remarks

WORKSHOP

alternative careers in science & round-table

This workshop is intended for early stage researchers and postdocs willing to explore alternative careers in science. The invited speakers will show their career paths and share important tips for researchers to engage into alternative careers in science after doing a PhD. In the end, a round-table will promote interaction between speakers and attendees. The workshop is limited to 25 participants that will be selected based on a short motivation statement.

SPEAKERS:

Alternative careers in science: working for a medical research charity | Julie Greenfield (Head of Research, Ataxia-UK)

Science, medical marketing and start-up investing – it is all about innovation! | Anke Caßing (Principal in High-Tech Grunderfonds investment firm, Germany)

Non-linear Careers: The Power of Pivots | Pedro Resende (Life sciences researcher and co-founder and director of Chaperone platform, Portugal). 

REGISTRATION FEES

Registration for this conference gives access to all scientific sessions, poster sessions, workshops and conference resources. A confirmation email will be sent after registration is completed. Registered participants will receive the full program with information and links to access the zoom meeting rooms one week prior to the event. 

The PhasAGE Consortium offers 5 registration fees for residents of least developed countries (List of LDC); select this option in the registration form to apply for this exemption and you will receive information prior payment deadline. 

REGISTRATION CLOSED 

REGISTRATION TYPE REGISTRATION FEE REGISTRATION DATES PAYMENT DEADLINE
REGULAR REGISTRATION
ACADEMIC - 25€

NON-ACADEMIC - 50€

21 JUNE - 1 OCTOBER 2021
1 OCTOBER 2021
LEAST DEVELOPED COUNTRIES
NA
21 JUNE - 26 JULY 2021
NA

Please note that the registration fee is non-refundable.

ABSTRACT INFORMATION

The PhasAGE consortium welcomes all the participants to submit an abstract to present their work as a short talk or an e-poster. The scientific committee will review the abstracts and select those for short talks and e-posters. 

Please download the available abstract template. Submit the abstract in the original .docx format, without figures and using Arial font size 10 pts. 

PhasAGE will offer the registration fee to MSc and PhD students and junior postdocs (PhD < 5 years) with selected abstracts for the short talks and poster presentations (first authors only). 

ABSTRACT SUBMISSION CLOSED 

ABSTRACT SHORT TALKS POSTERS
Each participant can submit only one abstract as first author.
A few of the submitted abstracts will be selected for short oral presentations
Poster presentations will have a selected morning session to promote ample time for discussion
Select the type of presentation in the abstract submission form.

Notification of abstract acceptance and selection for short-talks: 17 September 2021

Deadline for registration of participant with abstract submission: 21 September

Payment deadline of participants with submitted abstracts: 1 October 2021

ORGANIZING INSTITUTION

Institute for Molecular and Cell Biology (IBMC/i3S), University of Porto, Portugal

ORGANIZING COMMITTEE

Sandra Macedo-Ribeiro (IBMC/i3S, University of Porto, Portugal) 

Mónica Lopes-Marques  (IBMC/i3S, University of Porto, Portugal) 

Rita Vilaça (IBMC/i3S, University of Porto, Portugal) 

SCIENTIFIC COMMITTEE

Sandra Macedo-Ribeiro (IBMC/i3S, University of Porto, Portugal) 

Elsa Logarinho (IBMC/i3S, University of Porto, Portugal) 

Reto Gassmann (IBMC/i3S, University of Porto, Portugal) 

Salvador Ventura (Autonomous University of Barcelona, Spain)

Peter Tompa (VIB-VUB, Belgium)

Ludo Van Den Bosch (VIB-VUB, Belgium)

Silvio Tosatto (University of Padova, Italy)

Monika Fuxreiter (University of Padova, Italy)

PhasAGE early stage researchers group (PhasAGE project)

Contact information
For logistic issues, contact the i3S Events Management Unit: events@i3s.up.pt

For scientific issues, contact the PhasAGE team: phasageproject@i3s.up.pt 

Sponsors

Patronages

The Widespread Twinning PhasAGE is fully committed to gender balance by developing and supporting a diverse and inclusive community.